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#3056 Multi-Omic Characterization and Evolution of Neuroendocrine Neoplasm Organoids
Introduction: Molecular characterizations of neuroendocrine neoplasm (NENs) have unveiled candidate alterations associated with aggressiveness and suggested that the molecular link between neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) might be subtler than initially thought. For example, we have recently unveiled a new entity of pulmonary carcinoids (supra-carcinoids) with carcinoid-like morphology yet the molecular and clinical features of large cell neuroendocrine carcinoma (LCNEC). Testing hypotheses to explain aggressiveness and the possibility of progression or transition from NET to NEC through the accumulation of genetic anomalies requires in vitro and in vivo experimental models.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Foll M
Authors: Alcala N, Dayton T, Mangiante L, Delhomme T, Tabone-Egling S,
Keywords: organoids, omics, evolution, lung, pancreas, bioinformatics,
Introduction: RGETNE national NEN Registry comprises 74 hospitals from all regions of Spain.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Garcia Carbonero R, Jimenez-Fonseca P, Benavent M, Alonso V, Alonso T,
Keywords: GEP-NEN, tumor registry, survival, prognosis, epidemiology,
Introduction: Lung neuroendocrine tumors (NET) are classified as typical (TC) and atypical carcinoids (AT), according to their mitotic count and the presence of necrosis. However, a role for tumor side (right vs left) and location (central vs peripheric) has not been established so far.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: La Salvia A
Authors: La Salvia A, Trevisi E, Brizzi M, Espinosa Olarte P, Enguita A,
Keywords: Lung neuroendocrine tumors, tumor side (left versus right), tumor site (peripheric versus central), prognostic factors, survival,
Introduction: The negative notch regulator DLL3 has gained increasing attention in tumors with neuroendocrine features, in particular SCLC, LCNEC and neuroendocrine prostate cancer, both as prognostic marker and candidate therapeutic target. No data are available on the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Liverani C
Authors: Liverani C, Bongiovanni A, Pieri F, Foca F, Ravaioli S,
Keywords: DLL3, RB1, prognostic biomarker, GEP-NEN,
Introduction: The incidence of BM in NET is underestimated and there is no consensus on clinical features, diagnostic techniques, and treatment options.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Smiroldo V
Authors: Smiroldo V, Lania A, Pedicini V, Pepe G, Zerbi A,
Keywords: bone metastases, skeletal related event, survival, bisphosphonates, 68Ga-PET, 18FDG-PET, CT scan,